Might help if you tell folks what the rest of your system is, and what cabling you use now.
For my part I'd say once a system reaches a certain level speaker and interconnect cables make a difference in audible sound. I made a pair of interconnects recently using a combination of a silver and gold blend wire and silver wire, they made a very audible change from the copper ribbon ones that were being used. (for me a positive one) My speaker cables are Lenahan Ribbon ones.
But there are plenty that will say cables make little difference, and a handful that even say no dif